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Electronic nose to “sniff” dogs for deadly tropical disease

Fewer dogs in Brazil may be euthanized unnecessarily after researchers showed that a new test is 95% accurate in identifying the deadly disease Leishmaniasis.

The research is published in PLOS Neglected Tropical Diseases.

Dogs are regularly put down when they are believed to be harboring the parasite which causes the illness and death in humans.

A dog in Brazil having hair clipped for the test. Image credit: Lancaster University

Globally over 350 million people are at risk of infection with an estimated 300,000 cases annually, and approximately 3,500 deaths each year in Brazil alone. Although therapeutic drugs are available there is no vaccine.

Dogs harbor the parasite which can be transmitted to humans after sand flies bite the animals, so an infected dog is put down.

Lancaster University Ph.D. student Monica Staniek witnessed this first hand in Brazil when she met pet owners who had brought in dogs suspected of infection.

“One lady was really upset and in the corridor crying and it was very upsetting. Some people even hide their dogs.”

It is difficult to identify very accurately all the infected dogs that are passing on the parasite to sandflies and this means that many healthy dogs are put down

Now a team led by Professor Gordon Hamilton of Lancaster University working with a company called RoboScientific has shown that a new test based on the smell of infected dogs – using an electronic Nose- has an accuracy of around 95%.

“We collect some hair from the dog and test it in our kit which we call an “electronic nose”. This can “sniff” the odor of the hair and, it can tell if the dog is infected or not.

“It’s important that our approach can detect the parasite even if the dog looks healthy. It’s easy to spot a sick dog, the problem is the dogs that look well but aren’t.

“It also means that infected dogs can be identified earlier so they can be removed before they transmit the parasite.”

The e-nose approach seems to be highly reliable, simple to use and is non-invasive, as there is no need for a blood sample.

Its development also opens up opportunities to diagnose Leishmaniasis in humans and to test for other tropical diseases such as malaria, trypanosomiasis and Chaga’s disease.

Source: Lancaster University


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